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Polysarcosine: The Best Alternative of Poly (Ethylene Glycol)

[ Vol. 4 , Issue. 2 ]


Manu Singhai and Sankha Bhattacharya*   Pages 93 - 98 ( 6 )


Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by Weslay and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.


Polysarcosine, polypeptoid, PEGylation, nanomedicine, biomedical applications poly (Ethylene Glycol), N-methylated glycine.


Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab-142001, Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab-142001

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